1/19/2024 0 Comments Define dendrite pruning![]() Moreover, developmental pruning involves local degeneration and terminal retraction, morphologically resembling neurodegeneration associated with nerve injury and age-dependent neurodegenerative diseases. ![]() Aberrant pruning, which results in altered dendritic or axonal density in human brains, is often associated with neurological disorders, including autism spectrum disorder and schizophrenia ( Tang et al., 2014 Sekar et al., 2016). In mammals, some neurons in the central and peripheral nervous systems can prune their unwanted or incorrect axons/dendrites to establish proper wiring of the nervous systems ( O'Leary and Koester, 1993 Malun and Brunjes, 1996 Bagri et al., 2003 Riccomagno et al., 2012 Tapia et al., 2012). Developmental pruning widely occurs across the animal kingdom. Selective elimination of their unnecessary processes without causing neuronal death, referred to as pruning, is essential for the maturation of the nervous systems at late stages ( Luo and O'Leary, 2005 Riccomagno and Kolodkin, 2015 Schuldiner and Yaron, 2015). Thus, this study reveals a JNK-independent role of Raw in regulating the secretory pathway and thereby promoting dendrite pruning.ĭuring animal development, neurons often elaborate exuberant processes and connections at early stages. Mechanistically, Raw facilitates Nrg downregulation and dendrite pruning in part through regulation of the secretory pathway. Moreover, Raw is required to modulate the secretory pathway by regulating the integrity of secretory organelles and efficient protein secretion. Importantly, we show that Raw promotes endocytosis and downregulation of the conserved L1-type cell-adhesion molecule Neuroglian (Nrg) prior to dendrite pruning. Raw appears to regulate dendrite pruning via a novel mechanism, which is independent of JNK signaling. Here, we identify an important and cell-autonomous role of the membrane protein Raw in dendrite pruning of ddaC neurons. However, the molecular mechanisms underlying ddaC dendrite pruning remain elusive. Drosophila ddaC sensory neurons selectively prune their larval dendrites to sculpt the nervous system during early metamorphosis. Neuronal pruning is essential for proper wiring of the nervous systems in invertebrates and vertebrates.
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